Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930464 | 0.79 | ALDH1A1 (0.44) | TRPV4ALDH1A1HSD17B10TDP1MEN1 | |
| SCHEMBL4541616 | 0.76 | TRPV4 (0.36) | TRPV4ALDH1A1HSD17B10TDP1MEN1 | |
| SCHEMBL11348878 | 0.73 | ALDH1A1 (0.40) | TRPV4ALDH1A1HSD17B10TDP1CYP3A4 | |
| SCHEMBL3746673 | 0.72 | ALDH1A1 (0.56) | TRPV4ALDH1A1HSD17B10MEN1CYP1A2 | |
| SCHEMBL31453875 | 0.71 | TRPV4 (0.40) | TRPV4ALDH1A1HSD17B10MEN1CYP1A2 | |
| SCHEMBL2266737 | 0.71 | TRPV4 (0.36) | TRPV4ALDH1A1HSD17B10TDP1MEN1 | |
| SCHEMBL8764082 | 0.71 | TSHR (0.40) | TRPV4ALDH1A1HSD17B10 | |
| SCHEMBL4617086 | 0.71 | ALDH1A1 (0.50) | ALDH1A1HSD17B10TDP1MEN1PKM | |
| SCHEMBL4618011 | 0.70 | KMT2A (0.39) | TRPV4ALDH1A1MEN1CYP1A2PKM | |
| SCHEMBL27142253 | 0.70 | TRPV4 (0.35) | TRPV4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507763-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097607-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |