Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091751 | 0.84 | TDP2 (0.39) | ALDH1A1TSHRTDP2NSD2HSP90AA1 | |
| SCHEMBL2930464 | 0.82 | ALDH1A1 (0.44) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 | |
| SCHEMBL30039434 | 0.82 | ALDH1A1 (0.44) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 | |
| SCHEMBL4616553 | 0.80 | HTT (0.45) | ALDH1A1L3MBTL1KMT2AMEN1CYP2C19 | |
| SCHEMBL31453875 | 0.78 | TRPV4 (0.40) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 | |
| SCHEMBL4618011 | 0.77 | KMT2A (0.39) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 | |
| SCHEMBL29907244 | 0.77 | TRPV4 (0.35) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 | |
| SCHEMBL27142253 | 0.77 | TRPV4 (0.35) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 | |
| SCHEMBL251515 | 0.74 | KMT2A (0.37) | TRPV4ALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL4187153 | 0.72 | TRPV4 (0.35) | TRPV4ALDH1A1TSHRL3MBTL1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445440-B2 | Dimeric IAP inhibitors | NOVARTIS AG (CH) | 2013-05-21 | — | — | US | disclosed |
| EP-2539333-A1 | DIMERIC IAP INHIBITORS | Novartis AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104266-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | NOVARTIS AG (CH) | 2011-08-25 | — | — | US | disclosed |
| US-4438245-A | FOR LIGHT SENSITIVE ELEMENTS | FUJI PHOTO FILM CO., LTD. (JP) | 1984-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110206690-A1 | DIMERIC IAP INHIBITORS | XIAP, BIRC5, BIRC2 | TRPV4 4223/4885ALDH1A1 4127/4885TSHR 4630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.