Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209405 | 0.88 | CHRNA7 (0.38) | DRD3DRD2HTR2AKDM4EGAA | |
| SCHEMBL6212074 | 0.87 | DRD3 (0.46) | DRD3DRD2HTR2AADRA2CHTR3A | |
| SCHEMBL6208852 | 0.80 | DRD3 (0.48) | DRD3DRD2HTR2AADRA2CHTR3A | |
| SCHEMBL6208967 | 0.68 | DRD3 (0.72) | DRD3DRD2HTR2AADRA2CHTR3A | |
| SCHEMBL3285858 | 0.65 | ADRB1 (0.40) | DRD3DRD2HTR2AHTR3AMAPT | |
| SCHEMBL6208249 | 0.64 | DRD3 (0.72) | DRD3DRD2HTR2AHTR3AGAA | |
| SCHEMBL6208140 | 0.64 | DRD2 (0.72) | DRD3DRD2HTR2AADRA2CHTR3A | |
| SCHEMBL3286899 | 0.63 | DRD3 (1.00) | DRD3DRD2HTR2ASLC6A3 | |
| SCHEMBL7497044 | 0.62 | DRD3 (0.35) | DRD3DRD2HTR2ASLC6A3 | |
| SCHEMBL6210382 | 0.61 | DRD2 (0.66) | DRD3DRD2HTR2AADRA2CHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307463-B1 | PYRROLO 2,1-B]-[1,3]BENZOTHIAZEPINES AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS WITH ANTIPSYCHOTIC ACTIVITY | SIGMA TAU IND FARMACEUTI (IT) | 2005-01-26 | — | — | EP | disclosed |
| US-6710041-B2 | Pyrrolo[2,1-B][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-03-23 | — | — | US | disclosed |
| US-20030186959-A1 | Pyrrolo[2,1-b][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-10-02 | — | — | US | disclosed |
| EP-1307463-A1 | PYRROLO 2,1-B]-[1,3]BENZOTHIAZEPINES AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS WITH ANTIPSYCHOTIC ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010175-A1 | PYRROLO[2,1-b][1,3]BENZOTHIAZEPINES AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS WITH ANTIPSYCHOTIC ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030186959-A1 | Pyrrolo[2,1-b][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity | TPH1, GRIN2C, GRIN2B | DRD3 92/4885DRD2 48/4885HTR2A 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.