Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC3R | P41968 | 2/20 | 0.41 |
| ▸ | MC1R | Q01726 | 2/20 | 0.41 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041827 | 0.90 | CTSK (0.43) | CCR1HTRA1GPR132CTSKSMYD3 | |
| SCHEMBL4040649 | 0.90 | CTSK (0.42) | CCR1GPR132CTSKSMYD3ACE | |
| SCHEMBL4039411 | 0.90 | CTSK (0.43) | CCR1GPR132CTSKACE | |
| SCHEMBL4042695 | 0.90 | CHRNB2 (0.41) | GPR132CTSKPTAFR | |
| SCHEMBL4047844 | 0.89 | SMYD3 (0.35) | HTRA1DRD4MC4RMC3RMC1R | |
| SCHEMBL6211183 | 0.89 | CTSK (0.42) | HTRA1MC4RMC3RMC1RCTSK | |
| SCHEMBL4045831 | 0.89 | CTSK (0.51) | GPR132CTSKSMYD3ACE | |
| SCHEMBL4042752 | 0.88 | CTSK (0.52) | GPR132CTSKSMYD3ACE | |
| SCHEMBL4038224 | 0.88 | CTSK (0.44) | GPR132CTSKSMYD3ACETAAR1 | |
| SCHEMBL6210263 | 0.88 | CTSK (0.44) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |