Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065521 | 0.84 | TDP1 (0.53) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL18789074 | 0.79 | TDP1 (0.59) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL6209515 | 0.79 | TDP1 (0.44) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL31715931 | 0.78 | VCAM1 (0.59) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL1068675 | 0.78 | VCAM1 (0.59) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL29217568 | 0.76 | TDP1 (0.60) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL1068908 | 0.75 | TDP1 (0.50) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL1063282 | 0.75 | TDP1 (0.50) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL8293278 | 0.75 | TDP1 (0.50) | TDP1TSHRMAPTLMNAALDH1A1 | |
| SCHEMBL5766321 | 0.72 | TSHR (0.46) | TDP1TSHRMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004014900-A1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | ELI LILLY AND COMPANY (US) | 2004-02-19 | — | — | WO | disclosed |