Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PPM1B | O75688 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673157 | 0.88 | KDM4E (0.44) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL11666352 | 0.86 | MAPT (0.43) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5847055 | 0.82 | IKBKB (0.50) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL24417899 | 0.81 | IDO1 (0.52) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL17774896 | 0.80 | DGAT1 (0.41) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL23511720 | 0.76 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| Water SCHEMBL28292285 | 0.74 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL21477551 | 0.73 | KDM4E (0.50) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL9993737 | 0.73 | KDM4E (0.42) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5847061 | 0.73 | IDO1 (0.54) | MAPTALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907642-B1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6596726-B1 | Method of inhibiting epidermal growth factor by treating, with an effective inhibiting amount, a mammal, in need thereof inhibit the epidermal growth factor receptor and related receptors and, in particular, their tyrosine kinase enzyme | WARNER LAMBERT COMPANY | 2003-07-22 | — | — | US | disclosed |
| US-6335344-B1 | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases | PFIZER INC. | 2002-01-01 | — | — | US | disclosed |
| EP-0907642-A1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049688-A1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |
| US-5679683-A | USEFUL FOR TREATING CANCER, ARTHRITIS, PSORIASIS, VASCULAR RESTENOSIS AND ANGIOGENESIS | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |
| EP-0741711-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995019970-A1 | TRICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1995-07-27 | — | — | WO | disclosed |