Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TYR | P14679 | 1/20 | 0.55 |
| ▸ | DAO | P14920 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264494 | 0.86 | SMN1; SMN2 (0.56) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL1568299 | 0.81 | HPGD (0.59) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL30493818 | 0.81 | HPGD (0.55) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL12456653 | 0.81 | HPGD (0.55) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL19127755 | 0.79 | HPGD (0.56) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL4048148 | 0.77 | HSD17B3 (0.58) | HPGDAKR1B1POLBKDM4EALDH1A1 | |
| SCHEMBL15736793 | 0.76 | SMN1; SMN2 (0.53) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL28004016 | 0.76 | HPGD (0.49) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL9233565 | 0.75 | HPGD (0.47) | HPGDSMN1; SMN2TYRDAOAKR1B1 | |
| SCHEMBL7143389 | 0.75 | HPGD (0.51) | HPGDSMN1; SMN2TYRDAOAKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112321553-B | Method for synthesizing 3-position difluoromethyl substituted coumarin derivative from aryl alkyne acid ester | 天津科技大学 | 2022-11-08 | — | — | CN | disclosed |
| CN-112321553-B | Method for synthesizing 3-position difluoromethyl substituted coumarin derivative from aryl alkyne acid ester | 天津科技大学 | 2022-11-08 | — | — | CN | disclosed |
| CN-111364057-B | Method for continuously preparing C-3-position polyfluoromethyl substituted coumarin by using electrochemical microchannel reaction device | 中国药科大学 | 2022-04-29 | — | — | CN | disclosed |
| CN-112321553-A | Method for synthesizing 3-position difluoromethyl substituted coumarin derivative from aryl alkyne acid ester | 天津科技大学 | 2021-02-05 | — | — | CN | disclosed |
| CN-112321553-A | Method for synthesizing 3-position difluoromethyl substituted coumarin derivative from aryl alkyne acid ester | 天津科技大学 | 2021-02-05 | — | — | CN | disclosed |
| CN-111364057-A | Method for continuously preparing C-3-position polyfluoromethyl substituted coumarin by using electrochemical microchannel reaction device | 中国药科大学 | 2020-07-03 | — | — | CN | disclosed |
| US-20170073359-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MOLECULAR PROBES, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20160139135-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | LIFE TECHNOLOGIES CORP (US) | 2016-05-19 | — | — | US | disclosed |
| US-8865891-B2 | Optically-detectable enzyme substrates and their method of use | Life Technologies Corporation (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130090470-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | Life Technologies Corporation (US) | 2013-04-11 | — | — | US | disclosed |
| US-8318450-B2 | Optically-detectable enzyme substrates and their method of use | Life Technologies Corporation (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120040380-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | Life Technologies Corporation (US) | 2012-02-16 | — | — | US | disclosed |
| US-20090047692-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | INVITROGEN CORPORATION (US) | 2009-02-19 | — | — | US | disclosed |
| EP-1711504-A2 | DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACTAMASE IN A SAMPLE | Molecular Probes Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005071096-A9 | DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACAMASE IN A SAMPLE | — | 2006-02-02 | — | — | WO | disclosed |
| US-20050227309-A1 | Optically-detectable enzyme substrates and their method of use | MOLECULAR PROBES, INC. | 2005-10-13 | — | — | US | disclosed |
| WO-2005071096-A2 | DERIVATIVES OF CEPHALOSPORIN AND CLAVULANIC ACID FOR DETECTING BETA-LACAMASE IN A SAMPLE | MOLECULAR PROBES, INC. (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160139135-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MGAM, LCT, GAA | HPGD 650/4885SMN1; SMN2 1639/4885TYR 1033/4885 |
| US-20170073359-A1 | Optically-Detectable Enzyme Substrates and Their Method of Use | MGAM, LCT, GAA | HPGD 650/4885SMN1; SMN2 1639/4885TYR 1033/4885 |
| US-20130090470-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | MGAM, LCT, GAA | HPGD 650/4885SMN1; SMN2 1639/4885TYR 1033/4885 |
| US-20090047692-A1 | OPTICALLY-DETECTABLE ENZYME SUBSTRATES AND THEIR METHOD OF USE | MGAM, LCT, GAA | HPGD 650/4885SMN1; SMN2 1639/4885TYR 1033/4885 |
| US-20050227309-A1 | Optically-detectable enzyme substrates and their method of use | MGAM, LCT, GAA | HPGD 650/4885SMN1; SMN2 1639/4885TYR 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.