Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.43 |
| ▸ | PRKACA | P17612 | 3/20 | 0.43 |
| ▸ | PRKX | P51817 | 3/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6209835 | 1.00 | POLB (0.43) | POLBHPGDSMN1; SMN2ROCK2ROCK1 | |
| SCHEMBL6232713 | 0.85 | NPC1 (0.55) | HPGDSMN1; SMN2ROCK2ROCK1PRKACA | |
| SCHEMBL6209680 | 0.84 | CNR1 (0.44) | MAPK1RAB9ANPC1KMT2ACYP3A4 | |
| SCHEMBL6237990 | 0.84 | ALDH1A1 (0.44) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL6210753 | 0.81 | KMT2A (0.40) | HPGDSMN1; SMN2MAPK1RAB9ANPC1 | |
| SCHEMBL13655383 | 0.80 | LOX (0.42) | POLBROCK2ROCK1GSK3BRAB9A | |
| SCHEMBL6211363 | 0.79 | RAB9A (0.43) | POLBHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6211920 | 0.79 | RAB9A (0.43) | POLBHPGDSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6212969 | 0.78 | MME (0.38) | MAPK1RAB9ANPC1KMT2ACYP3A4 | |
| SCHEMBL4058914 | 0.77 | POLB (0.34) | POLBHPGDSMN1; SMN2ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299365-B1 | 2-AMINOTHIAZOLINE DERIVATIVES AND THEIR USE AS NO-SYNTHASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2005-09-28 | — | — | EP | disclosed |