Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.54 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966803 | 0.88 | KIF11 (0.68) | KIF11KIF23KCNH2MAP1LC3B | |
| SCHEMBL3957584 | 0.88 | KIF11 (0.57) | KIF11KIF23LMNAKCNH2TP53 | |
| SCHEMBL3958220 | 0.88 | KIF11 (0.63) | KIF11KIF23KCNH2MAP1LC3B | |
| SCHEMBL3961576 | 0.86 | KIF11 (0.57) | KIF11KIF23KCNH2MAP1LC3B | |
| SCHEMBL6207373 | 0.84 | KIF11 (0.53) | KIF11KIF23LMNATP53GAA | |
| SCHEMBL6209231 | 0.84 | KIF11 (0.53) | KIF11KIF23LMNATP53GAA | |
| SCHEMBL3959159 | 0.83 | KIF11 (0.60) | KIF11KIF23KCNH2MAP1LC3B | |
| SCHEMBL5246236 | 0.82 | KIF11 (0.52) | KIF11KIF23MC4R | |
| SCHEMBL3959566 | 0.82 | KIF11 (0.59) | KIF11KIF23KCNH2MAP1LC3B | |
| SCHEMBL6207429 | 0.82 | KIF11 (0.49) | KIF11KIF23 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |