Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 11/20 | 0.38 |
| ▸ | CTSS | P25774 | 8/20 | 0.38 |
| ▸ | CTSB | P07858 | 4/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214152 | 0.86 | CTSK (0.37) | CTSKRAB9ASMN1; SMN2CTSLCTSS | |
| SCHEMBL6214202 | 0.85 | CTSK (0.47) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4318514 | 0.80 | MAPK1 (0.36) | CTSKRAB9ASMN1; SMN2CTSLCTSS | |
| SCHEMBL4765494 | 0.80 | CTSK (0.40) | CTSKNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL6210362 | 0.80 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6215050 | 0.79 | CTSK (0.36) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4768354 | 0.76 | CTSB (0.34) | CTSKSMN1; SMN2CTSLCTSSCTSB | |
| SCHEMBL6213890 | 0.76 | CTSB (0.34) | CTSKSMN1; SMN2CTSLCTSSCTSB | |
| SCHEMBL7426317 | 0.74 | CTSK (0.37) | CTSKRAB9ASMN1; SMN2CTSLCTSS | |
| SCHEMBL7534924 | 0.73 | CTSK (0.42) | CTSKCTSLCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307203-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1307203-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001070232-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-27 | — | — | WO | disclosed |