Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 7/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19055875 | 0.91 | DPP4 (0.51) | DPP4DPP8DPP9CTSK | |
| SCHEMBL3966030 | 0.91 | DPP4 (0.51) | DPP4DPP8DPP9CTSK | |
| SCHEMBL82202 | 0.91 | DPP4 (0.51) | DPP4DPP8DPP9CTSK | |
| SCHEMBL65490 | 0.88 | HSD17B10 (0.63) | HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL77858 | 0.88 | HSD17B10 (0.63) | HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL65491 | 0.88 | HSD17B10 (0.63) | HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5898691 | 0.86 | HSD17B10 (0.62) | HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL18358031 | 0.86 | HSD17B10 (0.62) | HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL222955 | 0.86 | HSD17B10 (0.62) | HSD17B10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL240005 | 0.86 | DPP4 (0.56) | HSD17B10DPP4DPP8DPP9CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581525-A2 | COMPOUNDS HAVING AN ACTIVITY AT METABOTROPIC GLUTAMATE RECEPTORS | AstraZeneca AB (SE) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004014902-A2 | COMPOUNDS HAVING AN ACTIVITY AT METABOTROPIC GLUTAMATE RECEPTORS | ASTRAZENECA AB (SE) | 2004-02-19 | — | — | WO | disclosed |