Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 3/20 | 0.52 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL182948 | 0.90 | MAPT (0.85) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Phenazine SCHEMBL28253056 | 0.87 | MAPT (0.92) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Bicarbonate SCHEMBL11185192 | 0.86 | ALDH1A1 (0.58) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Bicarbonate SCHEMBL10870596 | 0.84 | TDP1 (0.75) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Bicarbonate SCHEMBL18191918 | 0.84 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Phenazine SCHEMBL28375190 | 0.84 | ALDH1A1 (0.56) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Phenazine SCHEMBL27643128 | 0.83 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Phenazine SCHEMBL9049 | 0.83 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Phenazine SCHEMBL29356959 | 0.83 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| Phenazine SCHEMBL27905609 | 0.82 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1148107-B1 | COATED BIOLOGICALLY ACTIVE GRAINS | CHISSO CORP (JP) | 2005-03-02 | — | — | EP | disclosed |
| EP-1148107-A1 | COATED BIOLOGICALLY ACTIVE GRAINS | Chisso Corporation (JP) | 2001-10-24 | — | — | EP | disclosed |