Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157834 | 0.93 | TDP1 (0.71) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL11206926 | 0.90 | TDP1 (0.75) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL29451077 | 0.87 | TDP1 (1.00) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL116696 | 0.87 | TDP1 (1.00) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| Phenazine SCHEMBL6213173 | 0.84 | MAPT (0.69) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL634399 | 0.82 | ALDH1A1 (0.72) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL10908621 | 0.81 | TDP1 (0.68) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL10562751 | 0.81 | ALDH1A1 (0.69) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL6992814 | 0.78 | TDP1 (0.56) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3701892 | 0.78 | TDP1 (0.56) | TDP1ALDH1A1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0183142-A2 | Preparation process of lithium salts of anionic dyes, preferably with reactive groups | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-06-04 | — | — | EP | disclosed |
| EP-0071168-B1 | WATER-SOLUBLE DISAZO COMPOUNDS AND BIS-(AMINO-PHENOXY)-ETHANE COMPOUNDS WITH FIBRE REACTIVE GROUPS AS TETRAZO COMPOUNDS, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AND THE USE OF THE DISAZO COMPOUNDS AS DYESTUFFS | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-01-30 | — | — | EP | disclosed |
| EP-0071168-A2 | Water-soluble disazo compounds and bis-(amino-phenoxy)-ethane compounds with fibre reactive groups as tetrazo compounds, process for the preparation of these compounds and the use of the disazo compounds as dyestuffs | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-02-09 | — | — | EP | disclosed |