Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL22721012 | 0.87 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| Phenazine SCHEMBL6213173 | 0.84 | MAPT (0.69) | ALDH1A1MAPTSMN1; SMN2KDM4ERAB9A | |
| Maleic Acid SCHEMBL28811648 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| Naphthalene SCHEMBL2834576 | 0.81 | HCAR2 (0.56) | ALDH1A1MAPTKDM4ELMNAHCAR2 | |
| Naphthalene SCHEMBL2834571 | 0.81 | HCAR2 (0.56) | ALDH1A1MAPTKDM4ELMNAHCAR2 | |
| Quinoxaline SCHEMBL12472662 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| Quinoxaline SCHEMBL27317932 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| Quinoxaline SCHEMBL27317931 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| Quinoxaline SCHEMBL12472665 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA | |
| Phenazine SCHEMBL182948 | 0.81 | MAPT (0.85) | ALDH1A1MAPTSMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117122600-A | Low dose brimonidine combination and uses thereof | 眼科治疗有限责任公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-114980839-A | Stable formulations of silk proteins | 蚕丝科技有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-113474011-A | Compositions and methods for promoting corneal tissue repair | 俄亥俄州立创新基金会 | 2021-10-01 | — | — | CN | disclosed |
| CN-110996954-A | Low dose brimonidine combinations and uses thereof | 眼科治疗有限责任公司 | 2020-04-10 | — | — | CN | disclosed |