Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213699 | 1.00 | F2RL3 (0.48) | F2RL3ALOX5APFEN1EPHX2BCHE | |
| SCHEMBL2539185 | 0.83 | F2RL3 (0.50) | F2RL3ALOX5APFEN1 | |
| SCHEMBL7997720 | 0.83 | F2RL3 (0.50) | F2RL3ALOX5APFEN1 | |
| SCHEMBL2200755 | 0.80 | CHRNB4 (0.58) | F2RL3ALOX5APFEN1 | |
| SCHEMBL3113607 | 0.79 | DPP4 (0.52) | F2RL3ALOX5APFEN1 | |
| SCHEMBL29007980 | 0.79 | DPP4 (0.48) | F2RL3ALOX5APFEN1 | |
| SCHEMBL2200803 | 0.79 | ALOX5AP (0.50) | F2RL3ALOX5APFEN1 | |
| SCHEMBL5139432 | 0.78 | GPR119 (0.47) | F2RL3ALOX5APFEN1GPR119 | |
| SCHEMBL6289529 | 0.78 | F2RL3 (0.49) | F2RL3ALOX5APFEN1EPHX2GPR119 | |
| SCHEMBL4343050 | 0.77 | ALOX5AP (0.46) | F2RL3ALOX5APFEN1EPHX2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569638-A1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004050085-A1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |