Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 7/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10300889 | 0.93 | TOP1 (0.40) | TOP1PIK3CAENPP1TGFBR1KDM4E | |
| SCHEMBL15977497 | 0.87 | PIK3CA (0.45) | TOP1PIK3CAENPP1TGFBR1ACVR1 | |
| SCHEMBL22422764 | 0.83 | TOP1 (0.44) | TOP1PIK3CAENPP1TGFBR1KDM4E | |
| SCHEMBL2801515 | 0.81 | TOP1 (0.53) | TOP1PIK3CAKDM4EMEN1USP2 | |
| SCHEMBL15977645 | 0.80 | ERN1 (0.40) | TOP1KDM4EACVR1ERN1GSK3B | |
| SCHEMBL19906445 | 0.79 | — | — | |
| SCHEMBL17227667 | 0.78 | PIK3CA (0.43) | TOP1PIK3CAACVR1 | |
| SCHEMBL20248882 | 0.77 | IKBKB (0.38) | TOP1ENPP1KDM4EMEN1USP2 | |
| SCHEMBL13556998 | 0.77 | ACVR1 (0.54) | PIK3CATGFBR1ACVR1ERN1 | |
| SCHEMBL17345167 | 0.75 | MAPT (0.50) | TOP1TGFBR1KDM4EMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287506-B1 | PHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |
| EP-3287506-A1 | PHENANTHRENE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-8129037-B2 | Phenanthrene derivative | MERCK PATENT GMBH (DE) | 2012-03-06 | — | — | US | disclosed |
| US-8129037-B2 | Phenanthrene derivative | MERCK PATENT GMBH (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | MERCK PATEN GMBH PATENTS & SCIENTIFIC INFORMATION (DE) | 2009-01-29 | — | — | US | disclosed |
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | MERCK PATEN GMBH PATENTS & SCIENTIFIC INFORMATION (DE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | LEF1, CRY1, WNT1 | TOP1 212/4885PIK3CA 4504/4885ENPP1 1462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.