Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6215057 | 0.93 | ALDH1A1 (0.58) | ABCB1PTGS2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6215352 | 0.92 | ABCB1 (0.51) | ABCB1PTGS2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6216167 | 0.84 | ABCB1 (0.51) | ABCB1PTGS2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6216763 | 0.84 | KDM4E (0.61) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL6218455 | 0.82 | LHCGR (0.62) | ABCB1PTGS2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL6218802 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL27473111 | 0.81 | MAPT (0.53) | ALDH1A1MAPTKDM4EHTTTSHR | |
| SCHEMBL6216455 | 0.81 | LHCGR (0.59) | ALDH1A1MAPTKDM4EHTTTSHR | |
| SCHEMBL6216192 | 0.81 | ALDH1A1 (0.62) | ALDH1A1MAPTL3MBTL1MAPK1KDM4E | |
| SCHEMBL6217994 | 0.80 | MEN1 (0.53) | ABCB1ALDH1A1MAPTL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | claimed |