Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13408067 | 0.81 | TBXAS1 (0.56) | CHRNB2CHRNA7CHRNA4TBXAS1BCHE | |
| SCHEMBL8253461 | 0.78 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4TBXAS1CYP3A4 | |
| SCHEMBL725448 | 0.77 | MAPT (0.61) | CHRNB2CHRNA7CHRNA4CYP3A4MAPT | |
| SCHEMBL11348399 | 0.77 | MAPT (0.65) | CHRNB2CHRNA7CHRNA4TBXAS1CYP3A4 | |
| SCHEMBL11965205 | 0.77 | TBXAS1 (0.52) | CHRNB2CHRNA7CHRNA4TBXAS1CYP3A4 | |
| SCHEMBL7749049 | 0.77 | TBXAS1 (0.52) | CHRNB2CHRNA7CHRNA4TBXAS1CYP3A4 | |
| SCHEMBL28857518 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA7CHRNA4CYP3A4MAPT | |
| SCHEMBL11372144 | 0.74 | KDM4E (0.65) | TBXAS1MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL11385201 | 0.73 | TBXAS1 (0.49) | CHRNB2CHRNA7CHRNA4TBXAS1MAPT | |
| SCHEMBL11561617 | 0.73 | TAAR1 (0.57) | CHRNB2CHRNA7CHRNA4TBXAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560584-A4 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1560584-A2 | FAB I INHIBITORS | Affinium Pharmaceuticals, Inc. (CA) | 2005-08-10 | — | — | EP | disclosed |
| WO-2003088897-A2 | FAB I INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2003-10-30 | — | — | WO | disclosed |