Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM6A | O15550 | 1/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14312991 | 0.79 | PARP1 (0.56) | PARP1ELANEMETSLC22A12 | |
| SCHEMBL3223274 | 0.77 | PARP1 (0.45) | PARP1KDM4EELANELIMK1L3MBTL1 | |
| SCHEMBL6644401 | 0.74 | KDM4E (0.46) | PARP1KDM4EELANEKDM6BKDM6A | |
| SCHEMBL9060883 | 0.74 | NOTUM (0.41) | PARP1KDM4EFEN1NOTUML3MBTL1 | |
| SCHEMBL3220693 | 0.72 | PARP1 (0.41) | PARP1KDM4EELANE | |
| SCHEMBL3216995 | 0.72 | PARP1 (0.41) | PARP1KDM4EELANELIMK1KDM6B | |
| SCHEMBL1666075 | 0.71 | NR3C1 (0.44) | KDM4ENR3C1NR3C2HTT | |
| SCHEMBL30241905 | 0.70 | SLC22A12 (0.56) | PARP1ELANEMETSLC22A12 | |
| SCHEMBL288413 | 0.70 | SLC22A12 (0.56) | PARP1ELANEMETSLC22A12 | |
| SCHEMBL3228768 | 0.69 | PARP1 (0.38) | PARP1KDM4EELANELIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565466-A2 | METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4 | Merck & Co., Inc. (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004048377-A2 | METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4 | MERCK & CO., INC. (US) | 2004-06-10 | — | — | WO | disclosed |