Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.68 |
| ▸ | PTPN7 | P35236 | 11/20 | 0.53 |
| ▸ | POLB | P06746 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | HSPA1A | P0DMV8 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 8/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | BLM | P54132 | 5/20 | 0.49 |
| ▸ | GAPDH | P04406 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MASP2 | O00187 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217839 | 0.84 | CDC25B (0.57) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL6678349 | 0.82 | PTPN7 (0.65) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL3610631 | 0.81 | CDC25B (1.00) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL6214848 | 0.78 | GAPDH (0.68) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL15300120 | 0.75 | GRK6 (0.78) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL6215376 | 0.74 | POLB (0.77) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL15321540 | 0.73 | CDC25B (0.60) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL17464572 | 0.71 | MAPT (0.64) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL17458742 | 0.71 | MAPT (0.64) | CDC25BPTPN7POLBKMT2AHSPA1A | |
| SCHEMBL6675758 | 0.70 | GAPDH (0.56) | PTPN7POLBKMT2AHSPA1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | claimed |
| EP-1411947-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2004-04-28 | — | — | EP | claimed |
| JP-2003522758-A | — | — | 2003-07-29 | — | — | JP | claimed |
| WO-2003013530-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-02-20 | — | — | WO | claimed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | claimed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | claimed |
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | disclosed |
| EP-1411947-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003013530-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-02-20 | — | — | WO | disclosed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | disclosed |