Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 3/20 | 0.56 |
| ▸ | HSPA1A | P0DMV8 | 2/20 | 0.56 |
| ▸ | HSPA8 | P11142 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MASP2 | O00187 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214303 | 0.96 | GAPDH (0.57) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6214848 | 0.90 | GAPDH (0.68) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6085506 | 0.79 | GAPDH (0.69) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6217839 | 0.78 | CDC25B (0.57) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6211796 | 0.76 | GAPDH (0.35) | GAPDHHSPA1AHSPA8 | |
| SCHEMBL6087749 | 0.73 | HSPA1A (1.00) | GAPDHHSPA1AHSPA8MEN1POLB | |
| SCHEMBL6951562 | 0.71 | CYP2C9 (0.37) | — | |
| SCHEMBL6217832 | 0.71 | MAPK1 (0.33) | — | |
| SCHEMBL6214662 | 0.70 | POLB (0.34) | MEN1POLBKMT2AL3MBTL1TDP1 | |
| SCHEMBL6217040 | 0.70 | CDC25B (0.68) | GAPDHHSPA1AHSPA8MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470110-A2 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 1,2,3,4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS | Grünenthal GmbH (DE) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003062202-A2 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACIDS | Grünenthal GmbH (DE) | 2003-07-31 | — | — | WO | disclosed |