Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 3/20 | 0.68 |
| ▸ | HSPA1A | P0DMV8 | 2/20 | 0.68 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.68 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675758 | 0.90 | GAPDH (0.56) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6214303 | 0.84 | GAPDH (0.57) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6087749 | 0.81 | HSPA1A (1.00) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6217040 | 0.78 | CDC25B (0.68) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6701529 | 0.78 | HSPA1A (0.79) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6641218 | 0.77 | GAPDH (0.42) | GAPDHHSPA1AHSPA8MEN1KMT2A | |
| SCHEMBL6085506 | 0.74 | GAPDH (0.69) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6678349 | 0.72 | PTPN7 (0.65) | GAPDHHSPA1AHSPA8PTPN7MEN1 | |
| SCHEMBL6212040 | 0.71 | MEN1 (0.40) | GAPDHHSPA1AHSPA8MEN1KMT2A | |
| SCHEMBL6213227 | 0.70 | MEN1 (0.39) | GAPDHHSPA1AHSPA8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | claimed |
| EP-1470110-A2 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 1,2,3,4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS | Grünenthal GmbH (DE) | 2004-10-27 | — | — | EP | claimed |
| EP-1411947-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2004-04-28 | — | — | EP | claimed |
| WO-2003062202-A2 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACIDS | Grünenthal GmbH (DE) | 2003-07-31 | — | — | WO | claimed |
| JP-2003522758-A | — | — | 2003-07-29 | — | — | JP | claimed |
| WO-2003013530-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-02-20 | — | — | WO | claimed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | claimed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | claimed |
| EP-1254118-B1 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | GRUENENTHAL GMBH (DE) | 2005-11-09 | — | — | EP | disclosed |
| EP-1470110-A2 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 1,2,3,4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS | Grünenthal GmbH (DE) | 2004-10-27 | — | — | EP | disclosed |
| EP-1411947-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003062202-A2 | METHOD FOR THE PRODUCTION OF SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE-2-CARBOXYLIC ACIDS | Grünenthal GmbH (DE) | 2003-07-31 | — | — | WO | disclosed |
| WO-2003013530-A2 | SALTS OF SUBSTITUTED 1, 2, 3, 4-TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES AS NMDA ANTAGONISTS | Grünenthal GmbH (DE) | 2003-02-20 | — | — | WO | disclosed |
| EP-1254118-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058875-A2 | SUBSTITUTED 1,2,3,4- TETRAHYDROQUINOLINE-2-CARBOXYLIC ACID DERIVATIVES | Grünenthal GmbH (DE) | 2001-08-16 | — | — | WO | disclosed |