Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217572 | 1.00 | VCAM1 (0.51) | VCAM1KAT2BMAPTKMT2AMAPK1 | |
| SCHEMBL2793482 | 0.85 | VCAM1 (0.54) | VCAM1KAT2BMAPTKMT2AMAPK1 | |
| SCHEMBL2793480 | 0.85 | VCAM1 (0.54) | VCAM1KAT2BMAPTKMT2AMAPK1 | |
| SCHEMBL1795604 | 0.83 | VCAM1 (0.51) | VCAM1KAT2BMAPTKMT2AMAPK1 | |
| SCHEMBL4554197 | 0.83 | TSHR (0.47) | TDP1RAB9ALMNAPDK1 | |
| SCHEMBL25295111 | 0.83 | CYP1A2 (0.39) | MAPK1RAB9APKMCYP1A2PDK1 | |
| SCHEMBL4554198 | 0.83 | TSHR (0.47) | TDP1RAB9ALMNAPDK1 | |
| SCHEMBL1795608 | 0.83 | VCAM1 (0.51) | VCAM1KAT2BMAPTKMT2AMAPK1 | |
| SCHEMBL3124584 | 0.82 | VCAM1 (0.45) | VCAM1KAT2BMAPTKMT2AMAPK1 | |
| SCHEMBL7965816 | 0.80 | VCAM1 (0.48) | VCAM1KAT2BMAPTKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367058-B1 | Tetrahydropyran derivatives | ASTELLAS PHARMA INC (JP) | 2005-11-09 | — | — | EP | disclosed |
| US-20050239780-A1 | Tetrahydropyran derivative | ASTELLAS PHARMA INC. (JP) | 2005-10-27 | — | — | US | disclosed |
| EP-1367058-A1 | Tetrahydropyran derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2003-12-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239780-A1 | Tetrahydropyran derivative | APOB, HDLBP, LDLR | VCAM1 988/4885KAT2B 2641/4885MAPT 4392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.