Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346881 | 0.88 | TUBB4A (0.48) | ALDH1A1TDP1LMNAMAPTKDM4E | |
| SCHEMBL20500983 | 0.88 | TUBB4A (0.48) | ALDH1A1TDP1LMNAMAPTKDM4E | |
| SCHEMBL3875000 | 0.82 | ALDH1A1 (0.45) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL12614866 | 0.80 | MAPT (0.46) | ALDH1A1LMNAMAPTKDM4ECYP3A4 | |
| SCHEMBL15649986 | 0.80 | MAPT (0.53) | ALDH1A1TDP1MAPTKDM4ECYP3A4 | |
| SCHEMBL10510116 | 0.80 | ALDH1A1 (0.44) | ALDH1A1TDP1LMNAMAPTKDM4E | |
| SCHEMBL12040936 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TDP1LMNAMAPTKDM4E | |
| SCHEMBL4349469 | 0.79 | GAA (0.50) | ALDH1A1TDP1CYP3A4PRKDCL3MBTL1 | |
| SCHEMBL18970268 | 0.78 | ALDH1A1 (0.51) | ALDH1A1TDP1LMNAMAPTKDM4E | |
| SCHEMBL16955366 | 0.78 | ALDH1A1 (0.47) | ALDH1A1TDP1LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495023-A1 | NOVEL 1,2,3-SUBSTITUTED INDOLIZINE DERIVATIVES, INHIBITORS OF FGFS, METHOD FOR MAKING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Sanofi-Aventis (FR) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003084956-A1 | NOVEL 1,2,3-SUBSTITUTED INDOLIZINE DERIVATIVES, INHIBITORS OF FGFS, METHOD FOR MAKING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI-AVENTIS (FR) | 2003-10-16 | — | — | WO | disclosed |