Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218948 | 0.84 | HTT (0.51) | MAPTHTTALDH1A1KDM4ENPC1 | |
| SCHEMBL3597910 | 0.79 | MAPT (0.47) | MAPTTP53NPC1GAA | |
| SCHEMBL11186148 | 0.79 | MAPT (0.41) | MAPTHTTTP53PDE4APDE4B | |
| SCHEMBL322335 | 0.76 | MAPT (0.45) | MAPTTP53ALDH1A1KDM4ELMNA | |
| SCHEMBL3602590 | 0.74 | NPC1 (0.40) | MAPTHDAC1HDAC6ALDH1A1KDM4E | |
| SCHEMBL27817268 | 0.74 | SMN1; SMN2 (0.41) | MAPTTP53PDE4APDE4BPDE4C | |
| SCHEMBL1573132 | 0.73 | MAPT (0.40) | MAPTTP53PDE4APDE4BPDE4C | |
| SCHEMBL145768 | 0.73 | HTT (0.55) | MAPTHTTALDH1A1KDM4ELMNA | |
| SCHEMBL1572852 | 0.71 | MAPT (0.42) | MAPTTP53 | |
| SCHEMBL28115592 | 0.71 | HTT (0.50) | MAPTHTTTP53ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1495023-B1 | NOVEL 1,2,3-SUBSTITUTED INDOLIZINE DERIVATIVES, INHIBITORS OF FGFS, METHOD FOR MAKING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2005-09-07 | — | — | EP | disclosed |