Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217836 | 0.92 | ALDH1A1 (0.53) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6220677 | 0.89 | POLB (0.40) | POLBKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6218162 | 0.87 | ALDH1A1 (0.37) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6218325 | 0.86 | NPC1 (0.46) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6198090 | 0.85 | NPC1 (0.45) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6219884 | 0.85 | ITGAL (0.40) | KDM4EMAPTKMT2A | |
| SCHEMBL6262430 | 0.85 | POLB (0.35) | POLBKDM4ESMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6220464 | 0.83 | ENPP2 (0.36) | KDM4EALDH1A1MAPTENPP2HPGD | |
| SCHEMBL6217834 | 0.82 | NPC1 (0.41) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6220749 | 0.81 | HTT (0.51) | NPC1RAB9APOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | claimed |