Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | IDE | P14735 | 1/20 | 0.55 |
| ▸ | MPI | P34949 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAP2 | P11137 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30366683 | 1.00 | KDM4E (0.62) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30393982 | 0.87 | KDM4E (0.57) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL756338 | 0.87 | KDM4E (0.57) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL28197191 | 0.86 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL5568381 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL30373749 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL61857 | 0.82 | MAP2 (0.62) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL29897041 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL2399274 | 0.80 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL87871 | 0.80 | KDM4E (0.65) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110423212-B | Hydroxy indole carboxylic acid-based inhibitors of SHP2 | 美国印第安纳大学研究和技术公司 | 2023-05-09 | — | — | CN | claimed |
| CN-105142634-B | Oxindole carboxylic acid-based inhibitors of oncogenic protein tyrosine phosphatase-2(SHP2) comprising Src homology-2domain | 美国印第安纳大学研究和技术公司 | 2020-06-12 | — | — | CN | claimed |
| US-9522881-B2 | Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-12-20 | — | — | US | claimed |
| US-20160102054-A1 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-04-14 | — | — | US | claimed |
| EP-2988741-A1 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | Indiana University Research&Technology Corporation (US) | 2016-03-02 | — | — | EP | claimed |
| WO-2014176488-A1 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2014-10-30 | — | — | WO | claimed |
| US-4459349-A | A 2-NAPHTHYL-4,5-DIPHENYLIMIDAZOLYL DIMER, UNSATURATED MONOMER | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1984-07-10 | — | — | US | claimed |
| JP-58015531-A | — | — | None | — | — | JP | disclosed |
| JP-58045210-A | — | — | None | — | — | JP | disclosed |
| CN-110423212-B | Hydroxy indole carboxylic acid-based inhibitors of SHP2 | 美国印第安纳大学研究和技术公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-110423212-B | Hydroxy indole carboxylic acid-based inhibitors of SHP2 | 美国印第安纳大学研究和技术公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-110423212-B | Hydroxy indole carboxylic acid-based inhibitors of SHP2 | 美国印第安纳大学研究和技术公司 | 2023-05-09 | — | — | CN | disclosed |
| US-20230034584-A1 | INHIBITORS OF SHP2 | BAYER AKTIENGESELLSCHAFT (DE) | 2023-02-02 | — | — | US | disclosed |
| US-4110464-A | INDOLOPYRONES HAVING ANTIALLERGIC ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1978-08-29 | — | — | US | disclosed |
| US-4087443-A | ANTIALLERGENS, ASTHMA | WARNER-LAMBERT COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4028383-A | DIMETHYLSULFONE REACTED WITH AN ESTER OF A SUBSTITUTED INDOXYLIC ACID | WARNER-LAMBERT COMPANY (US) | 1977-06-07 | — | — | US | disclosed |
| US-4013641-A | INDOLOBENZOXAZEPINES | XEROX CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |
| US-3976635-A | Novel esterifying agents, and their production and use | FUJISAWA PHARMACEUTICAL CO., LTD. (JA) | 1976-08-24 | — | — | US | disclosed |
| US-690332-A | ACYLATED INDOXYLIC ACID AND PROCESS OF MAKING SAME. | BASF AG (DE) | 1901-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102054-A1 | HYDROXYINDOLE CARBOXYLIC ACID BASED INHIBITORS FOR ONCOGENIC SRC HOMOLOGY-2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE-2 (SHP2) | SRC, PTPRCAP, PTPRJ | KDM4E 1178/4885ALDH1A1 2239/4885HPGD 2557/4885 |
| US-20230034584-A1 | INHIBITORS OF SHP2 | PTPN1, PTPN2, PTPRJ | KDM4E 842/4885ALDH1A1 3729/4885HPGD 4223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.