Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MTR | Q99707 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6219348 | 0.92 | MTTP (0.48) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL6219319 | 0.91 | MTTP (0.47) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Bicarbonate SCHEMBL7570482 | 0.91 | SLC6A12 (0.47) | ADRA1AHTR7DRD4CCR3HTR1A | |
| Bicarbonate SCHEMBL6216666 | 0.91 | MTTP (0.58) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Bicarbonate SCHEMBL6219322 | 0.90 | MTTP (0.49) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| Bicarbonate SCHEMBL6217318 | 0.90 | POLB (0.47) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7233534 | 0.89 | MTTP (0.45) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7235760 | 0.89 | HTR7 (0.45) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7241197 | 0.88 | KCNA3 (0.45) | MTTPCHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL7232099 | 0.87 | MTTP (0.43) | MTTPCHRM2ADRA2AADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-B1 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-03-09 | — | — | EP | disclosed |