Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7565338 | 0.91 | HTR7 (0.43) | HTR7KCNA3CCR3MEN1KMT2A | |
| SCHEMBL7570284 | 0.91 | SLC6A12 (0.47) | SLC6A12HTR7HTR1AKCNA3CCR3 | |
| Bicarbonate SCHEMBL6219363 | 0.91 | MTTP (0.47) | SLC6A12HTR7HTR1ACCR3MEN1 | |
| Bicarbonate SCHEMBL7570288 | 0.90 | SLC6A12 (0.49) | SLC6A12HTR7HTR1ACCR3MEN1 | |
| Bicarbonate SCHEMBL7570498 | 0.90 | MTTP (0.48) | HTR7UBE2MDCUN1D1CCR3MEN1 | |
| Bicarbonate SCHEMBL7564901 | 0.89 | POLB (0.48) | HTR7HTR1AKCNA3CCR3ADRA1A | |
| SCHEMBL7234407 | 0.87 | SLC6A12 (0.44) | SLC6A12HTR7HTR1AKCNA3CCR3 | |
| SCHEMBL7570480 | 0.86 | SLC6A12 (0.48) | SLC6A12HTR7HTR1AUBE2MDCUN1D1 | |
| SCHEMBL7238486 | 0.86 | HTR7 (0.43) | SLC6A12HTR7HTR1AUBE2MDCUN1D1 | |
| SCHEMBL7235323 | 0.86 | KCNA3 (0.45) | SLC6A12HTR7HTR1AUBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202969-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MEDICINES | Boehringer Ingelheim Pharma KG (DE) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005762-A2 | BIPHENYL DERIVATIVES, PRODUCTION THEREOF AND USE AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-25 | — | — | WO | disclosed |