Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7560936 | 0.78 | GAA (0.49) | NPC1MEN1KMT2ATRPV1SLC11A2 | |
| SCHEMBL27523784 | 0.72 | NPC1 (0.66) | NPC1MEN1KMT2ASLC11A2KCNMA1 | |
| SCHEMBL8027450 | 0.71 | HCAR1 (0.50) | NPC1MEN1KMT2ARAB9ACYP2C9 | |
| SCHEMBL11332310 | 0.70 | KMT2A (0.73) | NPC1MEN1KMT2AKCNMA1PHGDH | |
| SCHEMBL6857920 | 0.70 | KMT2A (0.73) | NPC1MEN1KMT2AKCNMA1PHGDH | |
| SCHEMBL31236765 | 0.70 | NPC1 (1.00) | NPC1MEN1KMT2AGAARAB9A | |
| SCHEMBL8925968 | 0.70 | KMT2A (0.67) | NPC1MEN1KMT2AKCNMA1PHGDH | |
| SCHEMBL113558 | 0.69 | MEN1 (0.71) | NPC1MEN1KMT2AKCNMA1PHGDH | |
| SCHEMBL1745798 | 0.69 | KMT2A (0.71) | NPC1MEN1KMT2AKCNMA1PHGDH | |
| SCHEMBL175272 | 0.69 | MEN1 (0.71) | NPC1MEN1KMT2AKCNMA1PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998051311-A2 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-11-19 | — | — | WO | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |