Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.75 |
| ▸ | CES1 | P23141 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.59 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28413498 | 0.98 | CES2 (0.72) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL29466797 | 0.86 | CES2 (1.00) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL29466796 | 0.86 | CES2 (1.00) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL211487 | 0.86 | CES2 (1.00) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL3035558 | 0.83 | CES2 (0.69) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL29976899 | 0.82 | CES2 (0.82) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL29358072 | 0.82 | — | — | |
| SCHEMBL55127 | 0.82 | — | — | |
| Methyl Alcohol SCHEMBL27687010 | 0.82 | ALDH1A1 (1.00) | CES2CES1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL6247730 | 0.81 | ALDH1A1 (0.67) | CES2CES1ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298878-A1 | OXIME COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. | 2009-12-03 | — | — | US | disclosed |
| US-6949564-B2 | for example, 9-ethyl-3-(5-methyl-4-phenyl-1H-imidazol-2-yl)-9H-carbazole; use in treating diseases, conditions and/or disorders modulated by NPY-5 receptor antagonists | PFIZER INC. (US) | 2005-09-27 | — | — | US | disclosed |
| EP-1575934-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NPY-5 ANTAGONISTS | Pfizer Products Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004055002-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NPY-5 ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2004-07-01 | — | — | WO | disclosed |
| US-20040122046-A1 | NPY-5 antagonists | PFIZER INC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298878-A1 | OXIME COMPOUNDS AND THE USE THEREOF | KCNN4, CACNA1A, KCNN3 | CES2 1256/4885CES1 1425/4885ALDH1A1 2105/4885 |
| US-20040122046-A1 | NPY-5 antagonists | NPY5R, NPY1R, NPY2R | CES2 3483/4885CES1 1400/4885ALDH1A1 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.