SCHEMBL6220196

SCHEMBL6220196

Cc1ccccc1-c1ncccc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 6/20 0.49
ADRA1A P35348 1/20 0.46
HSD11B1 P28845 4/20 0.45
PDK2 Q15119 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
AR P10275 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
HIF1A Q16665 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP2C19 P33261 1/20 0.41
TRPA1 O75762 2/20 0.40
TACR1 P25103 2/20 0.40
SCN5A Q14524 1/20 0.40
SCN9A Q15858 1/20 0.40
TRPM8 Q7Z2W7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14124513 0.84 HSD11B1 (0.44) TRPV1HSD11B1PDK2CYP1A2CYP3A4
SCHEMBL14124511 0.83 HSD11B1 (0.46) TRPV1HSD11B1CYP1A2CYP3A4AR
SCHEMBL6450954 0.82 RAB9A (0.57) HSD11B1TSHRMAPK1HSD17B10TDP1
SCHEMBL28937187 0.81 TRPV1 (0.46) TRPV1ADRA1AHSD11B1PDK2SCN5A
SCHEMBL5919362 0.81 ADRA1A (0.47) TRPV1ADRA1AHSD11B1PDK2CYP1A2
SCHEMBL15639061 0.79 HSD11B1 (0.49) TRPV1ADRA1AHSD11B1PDK2CYP1A2
SCHEMBL4160810 0.79 CYP2A6 (0.52) ADRA1ACYP1A2CYP3A4TDP1CYP2C19
SCHEMBL15624412 0.79 TRPV1 (0.47) TRPV1ADRA1A
SCHEMBL19968793 0.79 TRPV1 (0.44) TRPV1ADRA1AHSD11B1SCN5ASCN9A
SCHEMBL29464894 0.79 TRPV1 (0.44) TRPV1ADRA1AHSD11B1SCN5ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1569925-A1 2-SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS NEUROGEN CORPORATION (US) 2005-09-07 EP claimed
WO-2004055003-A1 2-SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS NEUROGEN CORPORATION (US) 2004-07-01 WO claimed
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-11-23 US disclosed
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-11-23 US disclosed
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-11-23 US disclosed
EP-4225737-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2023-08-16 EP disclosed
WO-2022076628-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMACEUTICALS INCORPORATED (US) 2022-04-14 WO disclosed
CN-109641873-B N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease 诺华股份有限公司 2022-03-18 CN disclosed
CN-109641873-A N- (pyridine -2- base) pyridine-sulfamide derivative and its purposes for disease treatment 诺华股份有限公司 2019-04-16 CN disclosed
CN-102898452-B Heterocyclic compound as TRPV1 blocker, pharmaceutical composition and medical application thereof ZHUHAI BEIHAI BIOTECH Co.,Ltd. (CN) 2016-12-14 CN disclosed
CN-1726205-A 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators NEUROGEN CORP (US) 2006-01-25 CN disclosed
EP-1581225-A1 COMBINATION THERAPY FOR THE TREATMENT OF PAIN NEUROGEN CORPORATION (US) 2005-10-05 EP disclosed
EP-1569926-A1 CARBOXYLIC ACID, PHOSPHATE OR PHOSPHONATE SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS NEUROGEN CORPORATION (US) 2005-09-07 EP disclosed
EP-1471910-A2 SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS MODULATORS OF CAPSAICIN RECEPTORS NEUROGEN CORPORATION (US) 2004-11-03 EP disclosed
WO-2004055004-A1 CARBOXYLIC ACID, PHOSPHATE OR PHOSPHONATE SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS CAPSAICIN RECEPTOR MODULATORS NEUROGEN CORPORATION (US) 2004-07-01 WO disclosed
WO-2004054582-A1 COMBINATION THERAPY FOR THE TREATMENT OF PAIN NEUROGEN CORPORATION (US) 2004-07-01 WO disclosed
WO-2003062209-A2 SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS MODULATORS OF CAPSAICIN NEUROGEN CORPORATION (US) 2003-07-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230373939-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR CFTR, SCNN1G, SCNN1B TRPV1 312/4885ADRA1A 1539/4885HSD11B1 3612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.