Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5904070 | 0.91 | HDAC1 (0.61) | HDAC1POLBBRAFGAAALDH1A1 | |
| SCHEMBL5903893 | 0.91 | HDAC1 (0.78) | HDAC1MEN1KMT2ACYP3A4HDAC3 | |
| SCHEMBL6197819 | 0.72 | HDAC1 (0.60) | HDAC1CYP3A4HDAC3HDAC2HDAC6 | |
| SCHEMBL6529911 | 0.71 | HDAC1 (0.64) | HDAC1CYP3A4HDAC3HDAC2HDAC6 | |
| SCHEMBL6246675 | 0.70 | HDAC6 (0.72) | HDAC1POLBGAAALDH1A1HSD17B10 | |
| SCHEMBL11230733 | 0.69 | ALDH1A1 (0.70) | HDAC1GAAALDH1A1HSD17B10KDM4E | |
| SCHEMBL5903852 | 0.69 | HDAC1 (0.58) | HDAC1ALDH1A1KDM4EL3MBTL1MEN1 | |
| SCHEMBL11426003 | 0.68 | ALDH1A1 (0.68) | HDAC1GAAALDH1A1HSD17B10KDM4E | |
| SCHEMBL9335999 | 0.68 | MAPT (0.50) | POLBALDH1A1HSD17B10KDM4EL3MBTL1 | |
| SCHEMBL5903880 | 0.67 | HDAC1 (0.84) | HDAC1KDM4EMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525199-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | Argenta Discovery Limited (GB) | 2005-04-27 | — | — | EP | claimed |
| WO-2004013130-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2004-02-12 | — | — | WO | claimed |