Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.51 |
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746091 | 0.93 | HTR2A (0.47) | HTR2ADRD2HTR7HTR1AHTR6 | |
| SCHEMBL6220399 | 0.88 | HTR2A (0.51) | HTR2ADRD2HTR7HTR1AHTR6 | |
| Hydrochloric Acid SCHEMBL6750990 | 0.88 | HTR2A (0.50) | HTR2ADRD2HTR7HTR1AHTR6 | |
| SCHEMBL6746149 | 0.84 | DRD2 (0.59) | HTR2ADRD2HTR7HTR1AKCNH2 | |
| SCHEMBL6748889 | 0.84 | ABCC1 (0.41) | HTR2ADRD2HTR7HTR1AHTR6 | |
| SCHEMBL6223321 | 0.84 | HTR1A (0.51) | HTR2ADRD2HTR7HTR1AKCNH2 | |
| SCHEMBL6743912 | 0.81 | HTR1A (0.53) | HTR2ADRD2HTR7HTR1AKCNH2 | |
| SCHEMBL6184200 | 0.78 | HTR2A (0.49) | HTR2ADRD2HTR7HTR1AKCNH2 | |
| SCHEMBL6747869 | 0.76 | PARP1 (0.49) | HTR2ADRD2HTR7HTR1AABCC1 | |
| SCHEMBL6747864 | 0.75 | HTR1A (0.44) | HTR2ADRD2HTR7HTR1AABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546143-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040138230-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | ANDREANA TONJA LYNN (US) | 2004-07-15 | — | — | US | disclosed |
| WO-2004026864-A1 | HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138230-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | CNR1, DRD2, CNR2 | HTR2A 16/4885DRD2 2/4885HTR7 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.