Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6249002 | 1.00 | HTR2C (0.43) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| SCHEMBL6217278 | 0.93 | HTR2C (0.43) | HTR2CHTR2AKCNH2HTR2BCHRM1 | |
| Hydrochloric Acid SCHEMBL6786724 | 0.90 | PIM1 (0.37) | HTR2CHTR2BPIM1PIM3PIM2 | |
| SCHEMBL6219238 | 0.87 | HTR2C (0.37) | HTR2CHTR2AKCNH2HTR2B | |
| SCHEMBL6216357 | 0.82 | KDM4E (0.41) | HTR2CHTR2AKCNH2HTR2B | |
| SCHEMBL7141991 | 0.80 | HTR2A (0.44) | HTR2CHTR2AKCNH2HTR2BHTR6 | |
| SCHEMBL7141988 | 0.80 | HTR2A (0.44) | HTR2CHTR2AKCNH2HTR2BHTR6 | |
| SCHEMBL10154877 | 0.79 | PGR (0.42) | HTR2CHTR2AKCNH2 | |
| SCHEMBL6216581 | 0.77 | GRIA1 (0.40) | HTR2C | |
| SCHEMBL6215612 | 0.77 | MEN1 (0.39) | HTR2CHTR2AKCNH2HTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414819-B1 | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES | PHARMACIA & UPJOHN CO LLC (US) | 2005-10-12 | — | — | EP | claimed |
| US-20030060464-A1 | Therapeutic 1H-pyrido [ 4, 3-b ] indoles | PHARMACIA & UPJOHN COMPANY | 2003-03-27 | — | — | US | claimed |
| EP-1414819-B1 | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES | PHARMACIA & UPJOHN CO LLC (US) | 2005-10-12 | — | — | EP | disclosed |
| US-6849640-B2 | Therapeutic 1H-pyrido [4,3-b] indoles | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20030060464-A1 | Therapeutic 1H-pyrido [ 4, 3-b ] indoles | PHARMACIA & UPJOHN COMPANY | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060464-A1 | Therapeutic 1H-pyrido [ 4, 3-b ] indoles | HTR3B, HTR4, HTR3C | HTR2C 12/4885HTR2A 18/4885KCNH2 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.