Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 1/20 | 0.50 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430879 | 0.75 | DGAT2 (0.49) | PBKDGAT2ALDH1A1LMNAMAPT | |
| SCHEMBL15786796 | 0.70 | ATR (0.54) | PBKDGAT2JAK2SYKJAK3 | |
| SCHEMBL28561328 | 0.69 | PBK (0.47) | PBKALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL18395530 | 0.68 | KMT2A (0.61) | PBKKDM4E | |
| SCHEMBL1290812 | 0.67 | GPBAR1 (0.57) | PBKALDH1A1GAAJAK2JAK3 | |
| SCHEMBL8235149 | 0.67 | PBK (1.00) | PBKJAK2JAK1JAK3ATR | |
| SCHEMBL883907 | 0.67 | CDC7 (0.58) | ALDH1A1MAPTHSD17B10KDM4EPIM1 | |
| SCHEMBL2451467 | 0.67 | TSHR (0.56) | PBKALDH1A1LMNAGAAMAPT | |
| SCHEMBL13662096 | 0.66 | CDK9 (0.50) | PBKALDH1A1LMNAGAAMAPT | |
| SCHEMBL23248642 | 0.66 | PIM2 (0.47) | PBKGAAPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551404-A2 | METHOD OF INHIBITING ANGIOGENESIS | Abbott Laboratories (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004032908-A2 | METHOD OF INHIBITING ANGIOGENESIS | ABBOTT LABORATORIES (US) | 2004-04-22 | — | — | WO | disclosed |