Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.56 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TYR | P14679 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16736821 | 0.86 | ALOX15 (0.71) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16736828 | 0.82 | ALDH1A1 (0.52) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL24871322 | 0.79 | ALDH1A1 (0.43) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL18262903 | 0.77 | ALDH1A1 (0.46) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL30573016 | 0.77 | ALDH1A1 (0.46) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16736855 | 0.77 | ALOX15 (0.46) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL16736832 | 0.77 | ALOX15 (0.46) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL12807736 | 0.77 | ALDH1A1 (0.46) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL1549203 | 0.76 | ALOX15 (0.43) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT | |
| SCHEMBL23421454 | 0.76 | ALDH1A1 (0.44) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250846-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | ANDERSON MARK B | 2005-11-10 | — | — | US | disclosed |
| EP-1560818-A1 | NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2005-08-10 | — | — | EP | disclosed |
| US-6903132-B2 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-06-07 | — | — | US | disclosed |
| US-20040014787-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | AGOURON PHARMACEUTICALS, INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003106446-A1 | NON-PEPTIDE GNRH AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |
| US-4588835-A | Process for preparing alkoxyphenols | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1986-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250846-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | GNRHR, LHCGR, FSHR | ALOX15 4695/4885ALDH1A1 4773/4885SMN1; SMN2 4129/4885 |
| US-20040014787-A1 | Non-peptide GnRH agents, pharmaceutical compositions and methods for their use | GNRHR, LHCGR, FSHR | ALOX15 4695/4885ALDH1A1 4773/4885SMN1; SMN2 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.