Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 5/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002852 | 0.74 | MEN1 (0.81) | MEN1KMT2ADRD4DRD2SLC18A3 | |
| SCHEMBL2554795 | 0.73 | HRH3 (0.40) | PRMT6CYP2D6CYP2C19 | |
| SCHEMBL1681215 | 0.72 | HRH3 (0.43) | CYP2D6CYP2C19 | |
| SCHEMBL12468741 | 0.72 | HRH3 (0.43) | CYP2D6CYP2C19 | |
| SCHEMBL467600 | 0.69 | MC4R (0.43) | PRMT6 | |
| SCHEMBL4053722 | 0.69 | SLC18A3 (0.62) | MEN1KMT2ADRD4DRD2SLC18A3 | |
| SCHEMBL8967407 | 0.69 | SLC18A3 (0.73) | MEN1KMT2ADRD2SLC18A3SIGMAR1 | |
| SCHEMBL11684911 | 0.69 | SLC18A3 (0.62) | MEN1KMT2ADRD4DRD2SLC18A3 | |
| SCHEMBL1003503 | 0.69 | DRD2 (0.73) | MEN1KMT2ADRD4DRD2SLC18A3 | |
| SCHEMBL2332535 | 0.68 | MEN1 (0.74) | MEN1KMT2ADRD4DRD2SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534689-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004024702-A1 | NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-03-25 | — | — | WO | disclosed |