Sugi Predict

Sugi Predict / Compounds / SCHEMBL622530

SCHEMBL622530

SCHEMBL622530

CCCCCC=CC[C@](C)(N)C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 6/20 0.50
▸ PPARD Q03181 5/20 0.50
▸ PPARA Q07869 5/20 0.50
▸ TERT O14746 3/20 0.50
▸ PTPN1 P18031 3/20 0.50
▸ MAPT P10636 3/20 0.50
▸ BLM P54132 3/20 0.50
▸ HSD17B10 Q99714 3/20 0.50
▸ FABP4 P15090 3/20 0.50
▸ TOP1 P11387 3/20 0.50
▸ KMT2A Q03164 3/20 0.50
▸ CYP1A2 P05177 2/20 0.50
▸ CYP2C19 P33261 2/20 0.50
▸ FAAH O00519 2/20 0.50
▸ USP2 O75604 2/20 0.50
▸ LMNA P02545 2/20 0.50
▸ ALOX15 P16050 2/20 0.50
▸ RECQL P46063 2/20 0.50
▸ F7 P08709 2/20 0.50
▸ CYP19A1 P11511 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL600895 1.00 PPARG (0.50) PPARGPPARDPPARATERTPTPN1
SCHEMBL11431507 0.84 ACLY (0.58) PPARGPPARDPPARATERTPTPN1
SCHEMBL8108031 0.84 ACLY (0.58) PPARGPPARDPPARATERTPTPN1
SCHEMBL3275097 0.81 ACLY (0.58) PPARGPPARDPPARATERTPTPN1
SCHEMBL1114649 0.80 ACLY (0.61) PPARGPPARDPPARATERTPTPN1
SCHEMBL1114645 0.80 ACLY (0.61) PPARGPPARDPPARATERTPTPN1
SCHEMBL5839448 0.79 GGT1 (0.42) MAPTBLMHSD17B10KMT2ACYP1A2
SCHEMBL6380325 0.79 GGT1 (0.42) MAPTBLMHSD17B10KMT2ACYP1A2
SCHEMBL5839453 0.79 GGT1 (0.42) MAPTBLMHSD17B10KMT2ACYP1A2
SCHEMBL6380315 0.79 GGT1 (0.42) MAPTBLMHSD17B10KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230127248-A1 PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF AILERON THERAPEUTICS, INC. 2023-04-27 — — US disclosed
US-20230119612-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2023-04-20 — — US disclosed
US-20230106577-A1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF AILERON THERAPEUTICS, INC. 2023-04-06 — — US disclosed
EP-3344275-B1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF AILERON THERAPEUTICS INC (US) 2023-03-08 — — EP disclosed
US-20230037284-A9 COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2023-02-02 — — US disclosed
CN-114853866-A Peptidomimetic macrocycles 艾瑞朗医疗公司 2022-08-05 — — CN disclosed
US-11339191-B2 Stapled peptides and uses thereof UNIVERSITE DE MONTPELLIER (FR) 2022-05-24 — — US disclosed
EP-3938051-A1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF Aileron Therapeutics, Inc. (US) 2022-01-19 — — EP disclosed
US-20220000968-A1 PEPTIDOMIMETIC MACROCYCLES HOFFMAN-LA ROCHE, INC. 2022-01-06 — — US disclosed
US-20210363189-A1 COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS INC (US) 2021-11-25 — — US disclosed
EP-2342214-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-07-13 — — EP disclosed
EP-2334697-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-06-22 — — EP disclosed
EP-2331567-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-06-15 — — EP disclosed
EP-2329015-A1 PEPTIDOMIMETIC MACROCYCLES Aileron Therapeutics, Inc. (US) 2011-06-08 — — EP disclosed
WO-2011038049-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2011-03-31 — — WO disclosed
WO-2010083347-A2 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-07-22 — — WO disclosed
WO-2010034029-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-03-25 — — WO disclosed
WO-2010034031-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-03-25 — — WO disclosed
WO-2010034028-A1 PEPTIDOMIMETIC MARCROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-03-25 — — WO disclosed
WO-2010034026-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2010-03-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230127248-A1 PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF MDM2, TP53, TP53BP1 PPARG 1421/4885PPARD 907/4885PPARA 1333/4885
US-20230119612-A1 PEPTIDOMIMETIC MACROCYCLES TP53, MDM2, MDM4 PPARG 3050/4885PPARD 2587/4885PPARA 2663/4885
US-20230037284-A9 COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES BID, FLT3, GRPR PPARG 2874/4885PPARD 3547/4885PPARA 3474/4885
US-11339191-B2 Stapled peptides and uses thereof IRAK2, IRAK1, IRAK3 PPARG 4397/4885PPARD 4047/4885PPARA 4108/4885
US-20230106577-A1 PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF TP53, TP53BP1, MDM2 PPARG 1140/4885PPARD 1668/4885PPARA 2146/4885
US-20220000968-A1 PEPTIDOMIMETIC MACROCYCLES TP53, MDM2, MDM4 PPARG 3050/4885PPARD 2587/4885PPARA 2663/4885
US-20210363189-A1 COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES BID, FLT3, GRPR PPARG 2874/4885PPARD 3547/4885PPARA 3474/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.