Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526465 | 0.87 | GAA (0.68) | GAASMN1; SMN2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL7832611 | 0.81 | GAA (0.54) | GAASMN1; SMN2MAPTALDH1A1MC4R | |
| SCHEMBL114482 | 0.79 | GPR119 (0.53) | GAASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL4710630 | 0.78 | MAPT (0.51) | GAASMN1; SMN2MAPTALDH1A1P2RX4 | |
| SCHEMBL5333413 | 0.77 | ALDH1A3 (0.52) | GAASMN1; SMN2MAPTALDH1A1KIT | |
| SCHEMBL6225314 | 0.77 | MAPT (0.53) | GAASMN1; SMN2MAPTALDH1A1KIT | |
| SCHEMBL5238295 | 0.76 | MAPT (0.42) | GAASMN1; SMN2MAPTALDH1A1P2RX4 | |
| SCHEMBL6809615 | 0.75 | CKS1B (0.53) | GAASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL6472002 | 0.74 | HTR2A (0.48) | GAASMN1; SMN2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL11160876 | 0.73 | MEN1 (0.52) | GAASMN1; SMN2MAPTALDH1A1P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572693-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004058762-A1 | MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITING COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |