SCHEMBL6225866

SCHEMBL6225866

C(=C/C1CCNCC1)\c1cncc(OCC2CC2)c1.CN1CCC(/C=C/c2cncc(OCC3CC3)c2)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB1 P11230 3/20 0.44
CHRNB2 P17787 3/20 0.44
CHRNB4 P30926 3/20 0.44
CHRNA3 P32297 3/20 0.44
CHRNB3 Q05901 3/20 0.44
AKT1 P31749 4/20 0.43
CYP2D6 P10635 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
HTR3A P46098 1/20 0.37
KCNH2 Q12809 1/20 0.37
CHUK O15111 1/20 0.36
DYRK3 O43781 1/20 0.36
ROCK2 O75116 1/20 0.36
MAP4K4 O95819 1/20 0.36
PIM1 P11309 1/20 0.36
PRKACA P17612 1/20 0.36
RPS6KB1 P23443 1/20 0.36
CLK2 P49760 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1349334 0.93 CHRNB2 (0.49) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349331 0.93 CHRNB2 (0.49) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349085 0.91 AKT1 (0.50) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349088 0.91 AKT1 (0.50) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349262 0.88 CHRNB2 (0.48) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349259 0.88 CHRNB2 (0.48) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349264 0.88 CHRNB2 (0.48) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349265 0.88 CHRNB2 (0.48) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL4754478 0.86 CHRNA3 (0.37) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3
SCHEMBL1349726 0.84 AKT1 (0.48) CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1601670-A1 ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF Targacept Inc. (US) 2005-12-07 EP disclosed
WO-2004078752-A1 ARYLVINYLAZACYCLOALKANE COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF TARGACEPT INC. (US) 2004-09-16 WO disclosed