Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917831 | 0.75 | PARP1 (0.41) | MAPK1PIM1FLT3BADPIM2 | |
| SCHEMBL6249030 | 0.73 | MAPK14 (0.53) | MAPTADORA3ADORA2AADORA1 | |
| SCHEMBL6480320 | 0.69 | MAPK14 (0.57) | HTTADORA3ADORA2A | |
| SCHEMBL30148789 | 0.69 | MAPT (0.37) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL29762231 | 0.68 | CYP1A2 (0.56) | MEN1KMT2AMAPTMAPK1ALDH1A1 | |
| SCHEMBL22606154 | 0.68 | ABCG2 (0.53) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL18554261 | 0.68 | TGFBR1 (0.70) | — | |
| SCHEMBL16146685 | 0.68 | LRRK2 (0.40) | MEN1KMT2AMAPTPIM1PIM2 | |
| SCHEMBL16146721 | 0.68 | BRAF (0.46) | MAPTPIM1PIM2ALDH1A1KDM4E | |
| SCHEMBL16146431 | 0.68 | LRRK2 (0.46) | MAPTPIM1PIM2HTTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551410-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004021979-A2 | PYRROLO[2, 3-d]PYRIMIDINE-4-YL AND PURIN-6-YL UREA COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-18 | — | — | WO | disclosed |