Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 1/20 | 1.00 |
| ▸ | RET | P07949 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.65 |
| ▸ | CA2 | P00918 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.65 |
| ▸ | AR | P10275 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL28188106 | 0.87 | DDR2 (0.77) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL9812764 | 0.85 | DDR2 (0.73) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL28338724 | 0.83 | ABCG2 (0.74) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL23611018 | 0.82 | DDR2 (0.70) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL29349443 | 0.81 | KMT2A (0.69) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL693914 | 0.81 | KMT2A (0.69) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL6508873 | 0.81 | DDR2 (0.68) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL4634257 | 0.80 | KMT2A (0.67) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL31717956 | 0.80 | KMT2A (0.67) | DDR2RETKDM4EKMT2AMEN1 | |
| SCHEMBL7703075 | 0.80 | PLA2G2A (0.73) | DDR2RETKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436601-B1 | CYTIDINE DEAMINASE EXPRESSION LEVEL IN CANCER AS A NEW THERAPEUTIC TARGET | CENTRE NAT RECH SCIENT (FR) | 2023-03-29 | — | — | EP | claimed |
| CN-106543155-A | As the chalcone and flavone derivative of aurora kinase inhibitors | 赵庆春 | 2017-03-29 | — | — | CN | claimed |
| CN-105481919-A | Flavone glycoside derivatives, and preparation method and application thereof | GUIZHOU BAILING GROUP PHARMACEUTICAL CO LTD | 2016-04-13 | — | — | CN | claimed |
| WO-2009055506-A2 | AMINOFLAVONE (NSC 686288) AND COMBINATIONS THEREOF FOR TREATING BREAST CANCER | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2009-04-30 | — | — | WO | claimed |
| CN-114555585-A | HPK1 inhibitors and uses thereof | 上海齐鲁锐格医药研发有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-111715083-B | Modified polyamide desalting layer, reverse osmosis membrane and preparation method and application thereof | 万华化学集团股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-106543155-B | Chalcone and flavonoid derivative as aurora kinase inhibitor | 中国人民解放军北部战区总医院 | 2020-07-07 | — | — | CN | disclosed |
| CN-106631820-A | Method for preparing aromatic amine compounds | 中国药科大学 | 2017-05-10 | — | — | CN | disclosed |
| US-9643960-B2 | Procaspase activating compounds | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-05-09 | — | — | US | disclosed |
| CN-106543155-A | As the chalcone and flavone derivative of aurora kinase inhibitors | 赵庆春 | 2017-03-29 | — | — | CN | disclosed |
| EP-2393794-B1 | DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS | UNIV ILLINOIS (US) | 2017-03-22 | — | — | EP | disclosed |
| WO-2017009382-A1 | USE OF A COORDINATION COMPOUND OF PLATINUM(II) AND THE METHOD FOR PRODUCING A COORDINATION COMPOUND OF PLATINUM(II) | Uniwersytet Medyczny w Łodzi (PL) | 2017-01-19 | — | — | WO | disclosed |
| CN-1541110-A | Methods for sterilizing prepns of monoclonal immunoglobulins | — | 2004-10-27 | — | — | CN | disclosed |
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-06-03 | — | — | US | disclosed |
| WO-2004004632-A2 | FLAVONE DERIVATIVES AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | NICHOLAS PIRAMAL INDIA LIMITED (IN) | 2004-01-15 | — | — | WO | disclosed |
| CN-1427729-A | Method for sterilizing biological materials | CLEARANT INC (US) | 2003-07-02 | — | — | CN | disclosed |
| EP-0173428-B1 | PROCESSES AND MATERIALS FOR CARRYING OUT MICROCHEMICAL AND MICROBIOLOGICAL TESTS | RADIOMETER CORPORATE DEVELOPMENT LIMITED (GB) | 1989-09-27 | — | — | EP | disclosed |
| US-4798788-A | Processes and materials for carrying out microchemical and microbiological tests | DADE BEHRING INC. | 1989-01-17 | — | — | US | disclosed |
| EP-0173428-A1 | Processes and materials for carrying out microchemical and microbiological tests | RADIOMETER CORPORATE DEVELOPMENT LIMITED (GB) | 1986-03-05 | — | — | EP | disclosed |
| WO-1986000341-A1 | PROCESSES AND MATERIALS FOR CARRYING OUT MICROCHEMICAL AND MICROBIOLOGICAL TESTS | UNILEVER NV (NL) | 1986-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106581-A1 | Inhibitors of cyclin-dependent kinases and their use | CCNK, CCNI, CDK1 | DDR2 1776/4885RET 785/4885KDM4E 1718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.