SCHEMBL6229003

SCHEMBL6229003

CCOC(=O)C12CC3CC(CC(CO)(C3)C1)C2

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.49
PKM P14618 1/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
LMNA P02545 2/20 0.44
ALDH1A1 P00352 3/20 0.42
GAA P10253 1/20 0.41
ATM Q13315 1/20 0.41
PRKCA P17252 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL691923 0.87 NPSR1 (0.61) NPSR1MEN1KMT2AL3MBTL1LMNA
SCHEMBL30091366 0.84 ALDH1A1 (0.48) NPSR1PKMALDH1A1GAA
SCHEMBL1846645 0.84 ALDH1A1 (0.48) NPSR1PKMALDH1A1GAA
SCHEMBL15432439 0.84 NPSR1 (0.46) NPSR1PKMMEN1KMT2AL3MBTL1
SCHEMBL685295 0.81 NPSR1 (0.44) NPSR1PKMMEN1KMT2AL3MBTL1
SCHEMBL5608298 0.81 ALDH1A1 (0.59) NPSR1MEN1KMT2AL3MBTL1LMNA
SCHEMBL12705434 0.81 PRKCA (0.47) NPSR1PKMMEN1KMT2AL3MBTL1
SCHEMBL1073543 0.79 LMNA (0.59) NPSR1PKMMEN1KMT2ALMNA
SCHEMBL19357098 0.79 POLB (0.41) MEN1KMT2ALMNAALDH1A1GAA
Hydrochloric Acid SCHEMBL27039883 0.79 NPSR1 (0.54) NPSR1PKMMEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1574495-A1 Adamantane derivatives Daicel Chemical Industries, Ltd. (JP) 2005-09-14 EP disclosed
EP-1574494-A1 Adamantane derivative Daicel Chemical Industries, Ltd. (JP) 2005-09-14 EP disclosed
US-6468487-B1 SUCH AS N-HYDROXYPHTHALIMIDE; DIRECTLY AND EFFICIENTLY REACTING ADAMANTANE WITH NITROGEN OXIDE OR WITH CARBON MONOXIDE AND OXYGEN DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2002-10-22 US disclosed
EP-0897747-A1 NITRATION OR CARBOXYLATION CATALYSTS Daicel Chemical Industries, Ltd. (JP) 1999-02-24 EP disclosed