Sugi Predict

Sugi Predict / Compounds / SCHEMBL6229502

SCHEMBL6229502

SCHEMBL6229502

Oc1cccc(Oc2cccc(C(F)(F)F)c2)c1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RAB9A P51151 1/20 0.56
▸ LTA4H P09960 1/20 0.47
▸ MAPT P10636 1/20 0.47
▸ KIF11 P52732 1/20 0.47
▸ TEAD1 P28347 1/20 0.46
▸ L3MBTL1 Q9Y468 2/20 0.46
▸ PPARG P37231 2/20 0.46
▸ MRGPRX4 Q96LA9 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.45
▸ CYP1A2 P05177 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ CYP2C19 P33261 1/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.44
▸ MAOB P27338 1/20 0.44
▸ AOC3 Q16853 1/20 0.44
▸ TLR8 Q9NR97 1/20 0.44
▸ TLR7 Q9NYK1 1/20 0.44
▸ ABCG2 Q9UNQ0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9589388 0.98 RAB9A (0.55) RAB9ALTA4HMAPTKIF11TEAD1
SCHEMBL9589666 0.96 RAB9A (0.54) RAB9ALTA4HMAPTKIF11TEAD1
SCHEMBL9798371 0.88 LTA4H (0.54) LTA4HMAPTKIF11TEAD1L3MBTL1
SCHEMBL4043144 0.87 LTA4H (0.53) LTA4HMAPTKIF11TEAD1MRGPRX4
SCHEMBL9589615 0.87 LTA4H (0.53) LTA4HMAPTKIF11TEAD1MRGPRX4
SCHEMBL9827905 0.87 RAB9A (0.55) RAB9ALTA4HMAPTKIF11
SCHEMBL9589071 0.86 LTA4H (0.52) LTA4HMAPTKIF11TEAD1ALDH1A1
SCHEMBL27579381 0.84 LTA4H (0.59) LTA4HMAPTKIF11TEAD1L3MBTL1
SCHEMBL6155481 0.84 TEAD1 (0.43) RAB9ALTA4HMAPTKIF11TEAD1
SCHEMBL13216570 0.83 CYP2C9 (0.51) LTA4HMAPTKIF11TEAD1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5219477-A Containing organometallic salts and inorganic metal borates; fromo reactinmetal hydroxide with phenols or aromatic carboxylic acid THE DOW CHEMICAL COMPANY (US) 1993-06-15 — — US claimed
US-11925651-B2 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2024-03-12 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF THE EHE FOUNDATION 2023-05-11 — — US disclosed
CN-115803317-A Azabicyclo (thio) amides as fungicidal compounds 拜耳作物科学股份公司 2023-03-14 — — CN disclosed
US-11458149-B1 TEAD inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-10-04 — — US disclosed
CN-114502540-A TEAD inhibitors and uses thereof 医肯纳肿瘤学公司 2022-05-13 — — CN disclosed
EP-3976192-A1 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2022-04-06 — — EP disclosed
WO-2020243423-A1 TEAD INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2020-12-03 — — WO disclosed
EP-1334086-A1 PHENOXYPHENYL ALKANE SULFONATES Bayer Aktiengesellschaft (DE) 2003-08-13 — — EP disclosed
US-20030022934-A1 Phenoxyphenyl alkanesulphonates BAYER AKTIENGESELLSCHAFT (DE) 2003-01-30 — — US disclosed
WO-2002026702-A1 PHENOXYPHENYL ALKANE SULFONATES BAYER AKTIENGESELLSCHAFT (DE) 2002-04-04 — — WO disclosed
US-5480568-A FOR LUBRICATING METAL CONTAINING SURFACES THE DOW CHEMICAL COMPANY (US) 1996-01-02 — — US disclosed
WO-1993024600-A1 OXIDATION-RESISTANT CYCLOPHOSPHAZENE FLUID INCLUDING TRIARYLPHOSPHINE OR PHOSPHINE OXIDE THE DOW CHEMICAL COMPANY (US) 1993-12-09 — — WO disclosed
US-5219477-A Containing organometallic salts and inorganic metal borates; fromo reactinmetal hydroxide with phenols or aromatic carboxylic acid THE DOW CHEMICAL COMPANY (US) 1993-06-15 — — US disclosed
US-5194652-A High temperature lubricants, hydraulic fluids; jet aircraft, turbines, diesel engines THE DOW CHEMICAL COMPANY (US) 1993-03-16 — — US disclosed
US-5118431-A Phthalonitriles and phthalocyanines as lubricity-enhancing additives THE DOW CHEMICAL COMPANY (US) 1992-06-02 — — US disclosed
US-5066409-A Novel aryl ether sulfones THE DOW CHEMICAL COMPANY (US) 1991-11-19 — — US disclosed
US-5061388-A Novel phthalonitriles and phthalocyanines as lubricity-enhancing additives THE DOW CHEMICAL COMPANY (US) 1991-10-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030022934-A1 Phenoxyphenyl alkanesulphonates SNCA, CLN6, NLN RAB9A 2935/4885LTA4H 683/4885MAPT 49/4885
US-20230148061-A1 TEAD INHIBITORS AND USES THEREOF TEAD2, TEAD3, TEAD4 RAB9A 1360/4885LTA4H 1854/4885MAPT 507/4885
US-11925651-B2 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 RAB9A 1360/4885LTA4H 1854/4885MAPT 507/4885
US-11458149-B1 TEAD inhibitors and uses thereof TEAD2, TEAD3, TEAD4 RAB9A 1360/4885LTA4H 1854/4885MAPT 507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.