Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5705691 | 0.81 | MAPT (0.52) | HTTMAPTMAPK1SLC6A3ALDH1A1 | |
| SCHEMBL15794120 | 0.75 | MAPT (0.44) | HTTMAPTMAPK1SLC6A3SLC6A2 | |
| SCHEMBL1834064 | 0.74 | RAB9A (0.48) | ALDH1A1SMN1; SMN2TSHRKITL3MBTL1 | |
| SCHEMBL13503893 | 0.73 | RAB9A (0.49) | ALDH1A1SMN1; SMN2TSHRKITL3MBTL1 | |
| SCHEMBL5737424 | 0.72 | HRH1 (0.60) | — | |
| SCHEMBL1693088 | 0.71 | RAB9A (0.44) | MAPTALDH1A1SMN1; SMN2KITL3MBTL1 | |
| SCHEMBL3986658 | 0.70 | HTT (0.41) | HTTMAPTMAPK1SLC6A3SLC6A2 | |
| SCHEMBL4596054 | 0.70 | GAA (0.45) | MAPTALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL704010 | 0.70 | RAB9A (0.51) | ALDH1A1HPGDKITMEN1KMT2A | |
| SCHEMBL4595299 | 0.69 | RAB9A (0.41) | HTTALDH1A1SMN1; SMN2KITL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517894-A1 | N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ ANTAGONISTS AND/OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004005255-A1 | N-BENZYL-3-PHENYL-3-HETEROCYCLYL-PROPIONAMIDE COMPOUNDS AS TACHYKININ AND/ OR SEROTONIN REUPTAKE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |