Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.64 |
| ▸ | TNFRSF1A | P19438 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6350350 | 0.88 | ABCG2 (0.60) | TNFRSF1AABCG2ABCB1TUBB1 | |
| SCHEMBL1204414 | 0.80 | HTT (0.72) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL30740894 | 0.80 | HTT (0.72) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL1134614 | 0.80 | TSHR (0.72) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL4895137 | 0.79 | ALDH1A1 (0.49) | TSHRTNFRSF1ASMN1; SMN2LMNAHPGD | |
| SCHEMBL30740936 | 0.78 | TSHR (0.70) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL985701 | 0.78 | TSHR (0.70) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL27914756 | 0.78 | TSHR (1.00) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL31520156 | 0.78 | TSHR (0.70) | TSHRAPOBEC3AHTTAPOBEC3GTNFRSF1A | |
| SCHEMBL18890189 | 0.78 | PKM (0.60) | HTTLMNAHPGDABCG2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513515-A2 | SUBSTITUTED 4H-CHROMENES, 2H-CHROMENES, CHROMANS AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003096982-A2 | SUBSTITUTED 4H-CHROMENES, 2H-CHROMENES, CHROMANS AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2003-11-27 | — | — | WO | disclosed |