Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alagebrium SCHEMBL1648822 | 0.82 | KMT2A (0.74) | KMT2APOLBOPRM1OPRD1MEN1 | |
| Bromide SCHEMBL3846653 | 0.81 | RAB9A (0.49) | KMT2APOLBMEN1MAPTALDH1A1 | |
| Alagebrium SCHEMBL1820212 | 0.81 | KMT2A (0.71) | KMT2APOLBOPRM1OPRD1MEN1 | |
| Alagebrium SCHEMBL225618 | 0.80 | KMT2A (0.69) | KMT2APOLBOPRM1OPRD1MEN1 | |
| SCHEMBL5070439 | 0.80 | ALDH1A1 (0.50) | KMT2APOLBMEN1MAPTPLA2G1B | |
| Bromide SCHEMBL3847792 | 0.80 | KMT2A (0.51) | KMT2APOLBOPRM1OPRD1MEN1 | |
| Bromide SCHEMBL6226270 | 0.78 | KMT2A (0.38) | KMT2AMEN1ALDH1A1KDM4EHPGD | |
| SCHEMBL4249680 | 0.78 | KMT2A (0.49) | KMT2APOLBOPRM1OPRD1MEN1 | |
| SCHEMBL6535188 | 0.77 | OPRM1 (0.58) | KMT2APOLBOPRM1OPRD1MEN1 | |
| Bromide SCHEMBL2947503 | 0.77 | OPRM1 (0.64) | KMT2APOLBOPRM1OPRD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098647-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING TISSUE ISCHEMIA | LONG ISLAND JEWISH RES INST (US) | 2005-03-23 | — | — | EP | disclosed |
| US-6391899-B1 | STROKE THERAPY; CARDIOVASCULAR DISORDERS | North Shore—Long Island Jewish Research Institute | 2002-05-21 | — | — | US | disclosed |