SCHEMBL6230486

SCHEMBL6230486

CN1CCC(COc2cc([N+](=O)[O-])ccc2C(F)(F)C(F)(F)F)CC1.O=[N+]([O-])c1ccc(C(F)(F)C(F)(F)F)c(OCC2CCNCC2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.44
CYP19A1 P11511 2/20 0.42
SIGMAR1 Q99720 2/20 0.40
CTSS P25774 1/20 0.38
CTSK P43235 1/20 0.38
HRH3 Q9Y5N1 1/20 0.37
F2 P00734 2/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
DNMT1 P26358 1/20 0.35
EHMT2 Q96KQ7 1/20 0.35
PDGFRA P16234 1/20 0.35
FLT3 P36888 1/20 0.35
MELK Q14680 1/20 0.35
HASPIN Q8TF76 1/20 0.35
HIF1A Q16665 1/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
RBP4 P02753 1/20 0.34
TTR P02766 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1655800 0.94 ACHE (0.48) ACHECYP19A1SIGMAR1HRH3F2
SCHEMBL445361 0.92 CYP19A1 (0.45) CYP19A1SIGMAR1CTSSCTSK
SCHEMBL449803 0.83 HRH3 (0.51) ACHECYP19A1SIGMAR1HRH3F2
SCHEMBL446992 0.82 ACHE (0.51) ACHECYP19A1SIGMAR1HRH3F2
SCHEMBL4937786 0.80 ACHE (0.49) ACHECYP19A1SIGMAR1CTSSCTSK
SCHEMBL450240 0.79 ALDH1A1 (0.47) CYP19A1F2MET
SCHEMBL4375016 0.78 CHRNB4 (0.61) CHRNB4CHRNA3
SCHEMBL5134516 0.78 CHRNB4 (0.61) CHRNB4CHRNA3
SCHEMBL4375014 0.78 CHRNB4 (0.61) CHRNB4CHRNA3
SCHEMBL426849 0.78 EGFR (0.45) HRH3PDGFRAFLT3MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1537084-A1 SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF Amgen Inc. (US) 2005-06-08 EP disclosed
WO-2004007458-A1 SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF AMGEN INC. (US) 2004-01-22 WO disclosed
EP-1358184-A1 SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE Amgen Inc. (US) 2003-11-05 EP disclosed
WO-2002066470-A1 SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE AMGEN INC. (US) 2002-08-29 WO disclosed