Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 3/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715742 | 0.86 | KDM4E (0.44) | NPC1BRD4RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6231126 | 0.81 | IKBKE (0.42) | PTGER1BRD4HTR1ASLC6A2SLC6A4 | |
| SCHEMBL4206891 | 0.77 | NR4A2 (0.44) | TSHRNR4A1NR4A2NR4A3KDM4E | |
| SCHEMBL4205180 | 0.72 | ALDH1A1 (0.55) | TSHRNPC1RAB9ASMN1; SMN2NR4A1 | |
| SCHEMBL25037414 | 0.72 | KDM4E (0.46) | PTGER1NPC1MRGPRX4NR4A1NR4A2 | |
| SCHEMBL30038623 | 0.72 | KDM4E (0.46) | PTGER1NPC1MRGPRX4NR4A1NR4A2 | |
| SCHEMBL30862699 | 0.70 | TSHR (0.45) | PTGER1TSHRMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL25037125 | 0.70 | TSHR (0.45) | PTGER1TSHRMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL4224922 | 0.70 | ALDH1A1 (0.53) | TSHRNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL21312413 | 0.70 | F10 (0.42) | PTGER1CPB1TSHRFFAR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003076443-A9 | SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY | BANYU PHARMA CO LTD (JP) | 2005-01-20 | — | — | WO | disclosed |
| EP-1483266-A1 | SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003076443-A1 | SPIRO COMPOUNDS WITH NPY ANTAGONISTIC ACTIVITY | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2003-09-18 | — | — | WO | disclosed |